What happens to enzymes if the body temperature is too high or if the pH in the body is too high or too low?

If body temperature is too high, enzymes can denature, losing their structure and functionality, which disrupts metabolic processes. Similarly, extreme pH levels can alter the ionization of amino acids in the enzyme's active site, impairing substrate binding and catalytic activity. Both conditions can lead to reduced enzyme activity and potentially harmful effects on the body's overall function. Maintaining optimal temperature and pH is crucial for enzyme activity and overall metabolic health.