Madame Defarge hates the Evremondes because the marquis (Charles Darnay/Evremonde's father) and his brother abused her family. Mme Defarge's sister's husband was seriously ill and died in her arms and Darnay's father raped her with the help of his older brother. Then the woman's brother found news of this and told his father and the news killed him from heartbreak. Then the boy hid young Mme Defarge (the younger sister) then was killed trying to save the raped sister. Very confusing but it all comes together coincidentally. Hope that helps!
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