Can you take aspirin with Vicodin?

In general, yes you can as they possess different mechanisms of action. Both hydrocodone (in Vicodin) and ibuprofen (Motrin) can be upsetting to the stomach, however. This is acceptable for short term use, however neither is meant to be taken chronically alone or together unless directed by a physician. Also, if you do decide to take these together, please run it by your doctor and/or pharmacist as this combination or one of the two may not be appropriate for all patients.