Can you take Tylenol 3 with amitriptyline?

Yes, you can generally take Tylenol 3 (which contains acetaminophen and codeine) with amitriptyline; however, it's important to do so under the guidance of a healthcare provider. Both medications can cause sedation, so combining them may enhance drowsiness. Always consult your doctor or pharmacist to ensure safety and to discuss any potential interactions based on your specific health conditions.