On a 2006 Ford E-250, the OBD (On-Board Diagnostics) fuse is located in the fuse box under the dashboard on the driver's side. You can find the fuse box by removing the cover panel beneath the steering wheel. The specific fuse for the OBD system is typically labeled in the fuse diagram found on the fuse box cover. If you're troubleshooting OBD issues, it's a good idea to check this fuse for continuity.
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