Is it safe to eat smoked salmon after being at room temperature for 48 hours?

No, it is not safe to eat smoked salmon that has been left at room temperature for 48 hours. Perishable foods, including smoked salmon, should not be left out for more than two hours to prevent the growth of harmful bacteria. Consuming it after such a long period could lead to foodborne illness. It's best to discard it to ensure safety.