The horseshoe with an exclamation point on your 2006 Acura MDX dashboard indicates a problem with the vehicle's tire pressure monitoring system (TPMS). This warning usually means that one or more tires may be under-inflated or there could be an issue with the TPMS itself. It's important to check your tire pressure and ensure all tires are properly inflated. If the light remains on after addressing the tire pressure, you should have the system inspected by a professional.
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