Angelman syndrome is primarily caused by a deletion or mutation in the UBE3A gene on maternal chromosome 15. Since it's generally not inherited in a typical Mendelian fashion, creating a Punnett square for Angelman syndrome is not straightforward. In cases of familial inheritance, if both parents are carriers of a UBE3A mutation, a Punnett square could illustrate the probabilities of offspring inheriting the condition, but this scenario is rare. Typically, the disorder arises de novo, meaning it occurs spontaneously in the child without being inherited from parents.
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