To flush the radiator of a 1995 GMC Vandura 2500 with a V6 engine, start by ensuring the engine is cool and then remove the radiator cap. Place a drain pan under the radiator and open the drain valve to let the old coolant flow out. Once drained, close the valve and fill the radiator with a mixture of water and radiator flush solution, running the engine for about 10-15 minutes to circulate the flush. Afterward, drain the system again, rinse with clean water, and refill with fresh coolant.
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