Where did the principles of respect for persons beneficence and justice first appear as applied to research?

The principles of respect for persons, beneficence, and justice were first articulated in the context of research in the Belmont Report, published in 1979 by the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research in the United States. This report was a response to ethical issues arising from past research practices, notably the Tuskegee Syphilis Study. It established these three fundamental ethical principles to guide researchers in the protection of human subjects in research.