How is a synaptic transmission terminated?

Synaptic transmission is terminated primarily through the reuptake of neurotransmitters by the presynaptic neuron, where they are repackaged into vesicles or broken down by enzymes. Additionally, neurotransmitters can be degraded by specific enzymes in the synaptic cleft, such as acetylcholinesterase for acetylcholine. Another mechanism involves the diffusion of neurotransmitters away from the synaptic cleft, reducing their concentration and effect on the postsynaptic receptors. Collectively, these processes ensure that the signal is brief and precisely regulated.