How do you come up with Threshold limit value for samples collected?

Threshold limit values (TLVs) for samples are typically established based on a combination of scientific research, exposure assessments, and health risk evaluations. Agencies like the American Conference of Governmental and Industrial Hygienists (ACGIH) review toxicological data, epidemiological studies, and industry practices to determine safe exposure levels. These values are also influenced by factors such as the duration and frequency of exposure, as well as the population's susceptibility. Ultimately, TLVs aim to protect workers' health by providing guidelines for safe exposure limits in occupational settings.