The sex of an offspring is primarily determined by the combination of sex chromosomes inherited from the parents. In humans, females typically have two X chromosomes (XX), while males have one X and one Y chromosome (XY). The sperm cell from the male parent can carry either an X or a Y chromosome, which, when combined with the X chromosome from the female parent, determines the sex of the offspring. If the sperm carries an X chromosome, the offspring will be female (XX); if it carries a Y chromosome, the offspring will be male (XY).
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