Yes. Drug overdoses often involve excruciating pain for several minutes, until either the person is unconcious or dead from the drug's other effects.
There was a time when common prescription medicine was pretty painlessly lethal, especially when combined with alcohol. That time, however, is passed, and those medications are not readily available nowadays.
Ergo -- best to avoid overdoses :}
Drug Overdosing will kill you , cause permanent brain and/or liver damage , and if you escape that, there is always having your stomach pumped and being court-ordered to a psychiatrist and possible criminal charges, as attempted suicide is against the law in most places in the US.
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