Why IgE is increased in wiskott-aldrich syndrome?

In Wiskott-Aldrich syndrome (WAS), there is a defect in the WAS protein, which is crucial for the signaling pathways involved in immune response and the regulation of immunoglobulin production. This defect leads to an imbalance in T-cell activation and promotes excessive IgE production, contributing to the characteristic allergic responses observed in patients. The increased IgE levels are also associated with the syndrome's symptoms, including eczema and increased susceptibility to infections.