Which episode of Desperate Housewives does Oprah Winfrey play in?

Oprah Winfrey guest stars in Season 2, Episode 23 of Desperate Housewives, titled "The Sun Won't Set." In this episode, she plays herself and appears during a segment where she interviews a character named Susan Mayer, played by Teri Hatcher. The episode revolves around various dramatic events on Wisteria Lane, culminating in a significant moment for the characters.