Can you practice as a doctor in America without USMLE?

Doctors of Medicine (M.D.) cannot be licensed in the United States without the United States Medical Licensing Examination; regarding Doctors of Osteopathic Medicine (D.O.) in the United States, many of these medical students take the USMLE, which is optional for them, but their mandatory licensure exam to practice as a physician is the Comprehensive Osteopathic Medical Licensing Examination.