When a heterozygous guinea pig (Rr) is mated with a homozygous recessive guinea pig (rr), the possible genotypes of their offspring are 50% Rr (heterozygous, rough coat) and 50% rr (homozygous recessive, smooth coat). This results in a genotype distribution of 1:1, with half of the offspring expected to have rough coats and the other half having smooth coats.
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