Which cells or tissues are affected by dengue?

Dengue virus primarily affects immune cells, particularly macrophages and dendritic cells, which are key components of the immune response. The virus can also impact endothelial cells lining blood vessels, leading to increased vascular permeability and contributing to symptoms like bleeding and plasma leakage. Additionally, liver cells may be affected, resulting in liver dysfunction in severe cases. Overall, the systemic nature of dengue can lead to widespread tissue involvement.