Will or can a permanent marker affect the skin when tattooing?

Using a permanent marker on the skin can pose risks when tattooing, as the ink may contain harmful chemicals that could cause skin irritation or allergic reactions. Additionally, the ink from permanent markers is not formulated for injection into the skin, which can lead to complications or unintended effects. It's best to use skin-safe, professional tattoo markers for outlining or preparing the skin before tattooing.