Margin of safety is protective than therapuetic index?

The margin of safety is considered more protective than the therapeutic index because it accounts for variability in individual responses to a drug. While the therapeutic index is the ratio between the toxic dose and the effective dose, the margin of safety provides a broader range of safety by considering the dose at which adverse effects occur in a larger population. This makes the margin of safety a more reliable measure for ensuring that a drug remains effective without reaching harmful levels, especially in vulnerable populations.