It is impossible to run Windows applications on a Macintosh computer?

It's not impossible to run Windows applications on a Macintosh computer. Users can utilize virtualization software like Parallels Desktop or VMware Fusion to run Windows alongside macOS, or they can use Boot Camp to install Windows natively on a separate partition. Additionally, some applications can be run using compatibility layers like Wine. Therefore, while Macs are not designed to run Windows apps natively, there are several effective solutions available.