When did the Spanish conquer Argentina?

The Spanish conquest of Argentina began in the early 16th century, with the first significant expedition led by Juan de Salazar y Espinosa in 1536, who founded Buenos Aires. However, the settlement was abandoned due to conflicts with indigenous peoples. A more successful colonization occurred in 1580 when Juan de Garay re-established Buenos Aires, leading to the gradual colonization of the region throughout the late 16th and 17th centuries.