What is the disadvantage of strobe using asynchtonous data transfer?

A disadvantage of using strobe signals in asynchronous data transfer is that it can lead to increased complexity in timing and synchronization. Since the strobe signal is used to indicate when data is valid, any mismatch in timing between the data and the strobe can result in data corruption or misinterpretation. Additionally, the reliance on strobe signals can increase the overhead in the system, potentially reducing overall data transfer efficiency.