I saw this in another answer, I'm not 100% sure it's her though:
The actress in the current Plavix commercial is Donna Bullock. Ms. Bullock Has been acting in movies, televsion and the stage since the late '70's. She has been featured in many television shows such as "Dallas", "Melrose Place", "Matlock", "Murder She Wrote", "Frasier", "24", "Monk", Medium", "JAG" and "Touched By an Angel", but may be best remembered as the doomed Press Secretary "Melanie Mitchell" in the Harrison Ford thriller, "Air Force One".
http://www.imdb.com/name/nm0120141/bio
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