Which was not an issue that led to sectionalism and regional disagreements in the US from 1820-1860?

One issue that did not significantly contribute to sectionalism and regional disagreements in the US from 1820 to 1860 was the debate over foreign policy. While domestic issues such as slavery, tariffs, and states' rights fueled tensions between the North and South, foreign policy largely united Americans in their interests and concerns. The focus during this period was predominantly on internal divisions rather than external relations.