Botulinum can be made by men or by a certain kind of bacteria. The remainder of this question, however, signals a serious misunderstanding of chemistry: Everything tangiblemade by man or any other life form consists of one or moreelements on the periodic chart. Botulinum is a compound, containing more than one element. It therefore can not be made from an* element but can be made from a small selection of elements.
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*Note that "an" is an article that can not correctly modify a plural subject.
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