What happens if you take Lunesta and Dexedrine at same time?

This addresses a classic question in psychopharmacology (how drugs affect the brain), of which I am a student. That question is about antagonistic drugs, in this example whether a CNS stimulant (Dexedrine) would "win" against a CNS depressant (Lunesta).

It is somewhat dependent on dosage, but not much. As long as the dexedrine was given in a half-significant amount, it would win out over Lunesta--you would not fall asleep. Lunesta would also reach a "plateau" in its depressive effects with an increase in dosage much more quickly than Dexedrine would.

In general, the rule of thumb in psychopharm is that given a strong enough stimulant, in a high enough dose, it will always win out over the depressant.

This rule is not entirely foolproof. 5mg dexedrine against 200mg sodium pentobarbital wouldn't do much in keeping you awake. But even a slightly higher amount of methamphetamine or cocaine would.

Hope that helps