Can you spay a 2 year old female dog?

If you spay your dog before its first heat, you cut out the risk of mammary cancer. Larger breeds should wait until around 15-18 months of age to be spayed. Yes, spaying at 2 years of age will lower your dog's risks of mammary cancer, pyometria, uterine infections, etc. No matter what the age, it is always best to spay your dog in order to get a longer and healthier life for them.