What part of the brain is affected by Ketamine?

Ketamine primarily affects the brain's glutamatergic system, particularly by blocking the N-methyl-D-aspartate (NMDA) receptor, which is crucial for synaptic plasticity and memory function. This action occurs mainly in the prefrontal cortex and limbic system, regions involved in mood regulation and cognition. Additionally, ketamine influences other neurotransmitter systems, including opioid receptors and gamma-aminobutyric acid (GABA), contributing to its anesthetic and antidepressant effects.