What was a negative effect of NativeAmericans trading with the colonists?

One negative effect of Native Americans trading with colonists was the introduction of European diseases, such as smallpox, to which Indigenous populations had no immunity, leading to significant population decline. Additionally, the trading relationships often led to dependency on European goods, undermining traditional economies and practices. This shift contributed to the erosion of Native American cultures and social structures, as they became increasingly integrated into the colonial economy.