What are the key differences between cadherins and integrins in terms of their functions and mechanisms of cell-cell adhesion?

Cadherins are cell adhesion proteins that mediate calcium-dependent cell-cell adhesion, while integrins are cell surface receptors that mediate cell-matrix adhesion. Cadherins are involved in homophilic interactions, meaning they bind to the same type of cadherin on neighboring cells, while integrins can bind to various extracellular matrix proteins. Cadherins are mainly responsible for maintaining tissue integrity and cell sorting, while integrins play a role in cell migration and signaling.