Does tay-sachs skip a generation

Tay-Sachs disease does not skip a generation in the traditional sense, as it is a genetic disorder caused by a mutation in the HEXA gene. It is an autosomal recessive condition, meaning a child must inherit two copies of the mutated gene (one from each parent) to develop the disease. If both parents are carriers of the mutation, there is a 25% chance with each pregnancy that their child will have Tay-Sachs. Thus, while it may appear to skip a generation if a carrier has children with someone who is not a carrier, the disease itself does not skip generations genetically.