What were the benefits and drawbacks of mission life for the Indians?

The imposition and suppression subjected upon the indigenous throughout North, South and Central America by the Imperial Spanish was a zero sum game for the Native Americans. The drawbacks were felt on the Natives through the loss of freedom, slavery, forced religious conversion, millions killed by disease, and the destruction of their way of life. The sole advantages to the mission came from the slave labor and seized property the Spanish conquistadors and missionaries forcibly took.