Why agomelatine increase the melatonin secretions?

Agomelatine is a synthetic antidepressant that acts as a melatonergic agent, specifically as a melatonin receptor agonist at MT1 and MT2 receptors. By stimulating these receptors, agomelatine mimics the action of natural melatonin, which helps regulate circadian rhythms and sleep-wake cycles. This agonistic effect can enhance the natural secretion of melatonin from the pineal gland, promoting better sleep and potentially alleviating symptoms of depression related to sleep disturbances. Additionally, agomelatine also influences serotonin receptors, which may further contribute to its overall effects on mood and sleep.