Has their ever been a female horse win the triple crown?

Yes, there has been a female horse that won the Triple Crown of Thoroughbred Racing in the United States. The most notable example is Regret, who won the Kentucky Derby in 1915. However, it is important to note that the Triple Crown typically refers to the three major races: the Kentucky Derby, the Preakness Stakes, and the Belmont Stakes, and no female horse has won all three races in a single season.