Amphetamine works as a dopamine transport substrate where as methylphenidate works as a dopamine transport blocker. Methylphenidate is most active at modulating levels of dopamine and to a lesser extent noradrenaline and serotonin.
Methylphenidate has a chemical structure more closely related to cocaine.
Amphetamine works by increasing extracellular levels of dopamine, noradrenaline and serotonin. With a highly adrenergic effect. There for the Word speed.
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