Is research conducted overseas is subject to hhs human subjects regulations local regulations and policies?

Yes, research conducted overseas involving human subjects is subject to the U.S. Department of Health and Human Services (HHS) human subjects regulations, specifically 45 CFR 46. However, researchers must also comply with local regulations and ethical guidelines of the host country. In cases where local laws are more stringent than HHS regulations, the more protective standards should be followed. Additionally, institutional review boards (IRBs) may require adherence to both sets of regulations to ensure ethical conduct.