When and where was the last F-5 tornado to hit in the US?

The last F5 or EF5 tornado to hit the United States was on May 20, 2013 in Moore, Oklahoma.

The last U.S. tornado to be rated F5 on the original Fujita scale (though EF5 is essentially the same rating) was the Bridgecreek-Moore, Oklahoma tornado of May 3, 1999.