How did descartes affect the 18th and 19th century?

How did descartes affect the 18th and 19th century?"

Descartes is often regarded as the first thinker to provide a philosophical framework for the natural sciences as these began to develop. Most famously, this is known as ( "I think, therefore I am"). "The simple meaning of the phrase is that if one is skeptical of existence, that is in and of itself proof that he does exist."