Is depakote given for seizure prophylaxis at high doses of clozapine?

Yes, Depakote (valproate) can be used for seizure prophylaxis in patients who are on high doses of clozapine. Clozapine is known to lower the seizure threshold, increasing the risk of seizures, especially at higher doses. Depakote helps to mitigate this risk by stabilizing neuronal activity. However, any treatment decision should be made based on an individual patient's clinical situation and under the guidance of a healthcare professional.