The Justinian Plague, which occurred from 541 to 542 AD, was characterized by its high mortality rate, with estimates suggesting it killed millions across the Byzantine Empire. Caused by the Yersinia pestis bacterium, it manifested in several forms, including bubonic, septicemic, and pneumonic plague. Symptoms included fever, chills, and painful swollen lymph nodes known as buboes. The outbreak had profound social and economic impacts, contributing to the decline of the Byzantine Empire.
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