What setbacks did Ivan the terrible had?

Ivan the Terrible faced several setbacks during his reign, including the death of his beloved wife, Anastasia, in 1560, which led to a period of paranoia and increased tyranny. His military campaigns, particularly against the Polish-Lithuanian Commonwealth and the Livonian War, were largely unsuccessful, draining resources and diminishing his reputation. Additionally, internal strife and the rise of the boyars challenged his authority, culminating in a violent period known as the Oprichnina, which alienated many of his subjects and led to widespread suffering.