Can you take Depo-Provera if you're on Mirena?

Mirena is more effective than Depo Provera, and is associated with less irregular bleeding. It lasts longer, does not depend on a woman returning to the office every twelve weeks, and has a quicker return to fertility after stopping than Depo Provera. Some women can't use the IUD due to unusual uterine anatomy, and for them, Depo may be a better option. Talk to your health care provider for advice specific to your situation.