Indomethacin and nabumetone are both nonsteroidal anti-inflammatory drugs (NSAIDs), but their potencies differ. Indomethacin is generally considered to be more potent than nabumetone on a milligram-to-milligram basis. Therefore, 50 mg of indomethacin is likely to have a stronger anti-inflammatory effect compared to 500 mg of nabumetone, although individual responses can vary. It's always best to consult a healthcare professional for specific medication concerns.
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