The conflict between Syria and the US primarily escalated during the Syrian Civil War, which began in 2011. The US opposed the regime of President Bashar al-Assad, accusing it of human rights abuses and using chemical weapons against civilians. The US also supported various opposition groups and conducted military operations against ISIS in Syria, complicating its relationship with the Syrian government and its allies, including Russia and Iran. Additionally, the US imposed sanctions on Syria, further straining diplomatic ties.
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