What is the best test for Nephrogenic Systemic Fibrosis?

The best test for Nephrogenic Systemic Fibrosis (NSF) is a skin biopsy, where histological examination reveals characteristic findings such as thickened collagen bundles and an increased number of fibroblasts. Additionally, MRI findings may show soft tissue edema or fibrosis, but these are not definitive. Laboratory tests for elevated serum creatinine and a history of gadolinium-based contrast agent exposure can also support the diagnosis. Ultimately, a combination of clinical evaluation, imaging, and biopsy results is used to confirm NSF.