Difference between space shuttle and space probe?

The Space Shuttle is a large, complex, manned spacecraft that is designed to carry people, satellites, probes, parts of space stations, or experiments into low-Earth orbit. It is re-usable and has flown many times.

Probes, on the other hand, are small, unmanned, robotic spacecraft that are sent to explore other moons, planets, or asteroids. There are many different types of probes, each designed for a specific mission. Probes are not re-usable and are destroyed or abandoned after they have completed their missions. Several examples of probes include the Galileo spacecraft, the Voyager spacecraft, the Mariner spacecraft, and the Mars Exploration Rovers Spirit and Opportunity.