One must always do their own research before messing around, especially when it comes to drug combinations. However, my personal understanding through my own research and experiences is that yes you can mix hydrocodone and LSD, whether it is a good idea depends on a variety of factors. If you are physically dependent on hydrocodone and need to take it just to feel well then it probably wouldn't have much of any impact on an LSD experience. If you have no hydrocodone tolerance and are totally "opioid naive" than it may be dangerous, LSD is so unpredictable in it's effects on the mind that there is always a risk you could overdo it and take too much hydrocodone, which is the only danger in the mix, as it can cause you to stop breathing and die (respiratory arrest), especially if alcohol is used in the mix, which many people use with LSD. If used with prudence by an experienced individual however, it may take away some of the potential LSD associated anxiety and add a different dimension or glow to the experience, depending on when the hydrocodone dose is administered (early on, at the end, or all throughout?).....The hydrocodone also may diminish some of LSD's effects as well....
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