What CBRNE agent is accompanied with a highly destructive explosion that instantly devastates people and buildings because of extreme heat and impact of the blast (All Hazards page 25 of 35)?

The CBRNE agent that is accompanied by a highly destructive explosion, instantly devastating people and buildings due to extreme heat and blast impact, is a nuclear weapon. The explosion from a nuclear detonation produces a massive shockwave and intense thermal radiation, causing widespread destruction and loss of life in the immediate vicinity.